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Overview of Clinical Trial 13-213 and summary statements: One of the main criticisms of NOM in patients with LARC is the poor correlation between cCR (based on both clinical examination and imaging studies) and pCR to neoadjuvant therapy. However, response has typically been assessed a few weeks after completion of neoadjuvant therapy, before some tumors have achieved maximal response, and before treatment-related tissue changes have had an opportunity to subside. This will be the first study to investigate the accuracy of clinical examination and imaging studies in ...